Our Cardiac biomarker reader Nano-Bots, currently under development, is a point-of-care in-vitro diagnostic testing system that measures the cardiac biomarker b-type natriuretic peptides (BNP) in blood quantitatively to aid the diagnosis of heart failure. Our system utilizes nanomaterial-based sensor technology with artificial intelligence / machine-learning-based data analysis module that can measure BNP concentration rapidly and accurately with one drop of blood.
The system operates like a blood glucose meter, where patient simply prick his/her finger using a lancet and fill the Nano-Bots test strip with finger-prick blood. Within a short time, the level of BNP will be displayed on the reader screen.
Our system is designed to deliver fast and accurate results at point-of-care such as clinics and patient home. For home use, the test results will be transferred to patient’s smartphone, which will then be uploaded to cloud server that can be access by doctors.
The system consists of a miniature multi-use electronic readout unit, single-use/disposable test strips and software with artificial intelligence (AI)/machine learning (ML)-based data processing capability.
- The Nano-Bots reader can perform electrochemical impedance spectroscopy (EIS) and data processing. It is a credit-card-sized portable electronics that connects to a laptop or tablet as a dongle. The software installed in a laptop, or a tablet gives instruction for operation and process the EIS data using the machine learning model. And to integrate the software of machine learning model into the reader is another option in next step development.
- The test strip consists of an array of fully electrical immunosensors on a plastic substrate and microfluidic channels guiding blood flow from the sample inlet to the active areas of individual sensors. Each immunosensor consists of a thin film of single-walled carbon nanotubes (SWNT) bridging a pair of metal contacts. Monoclonal anti-BNP antibodies are anchored on the SWNT network as high-affinity receptors for the specific capture of BNPs onto the SWNT surface. The BNP-antibody binding on the SWNT surface modulates SWNT conductivity and thus induces a change in the overall electrical impedance of each sensor that is proportional to BNP concentrations in whole blood. Upon addition of a blood sample, the change in electrical impedance caused by BNP-antibody binding stabilizes. Therefore, test results become available.
- Data processing software is based on artificial intelligence (AI)/machine learning (ML) technology.
Reader with screen Solution
The System provides the functions of telemedicine, medical database, and doctor remote monitoring. The data transfer could be finished by blue-tooth, cloud Server and finally to hospital Intra-net.
Reader without screen Solution
The Nano-Bots system is a technology platform that is designed to function as a building block for a variety of biomarker tests.
And the design of Nano-Bots system is easy to expend the test menu and suited for multiplex detection. a test strip is consisting of 20 SWNT sensors grouped in more than one areas is added to the sample reservoir, it flows through a microfluidic device and separated into paths and test different multi-determinand.